Prostate-specific antigen (KLK3)

About Prostate-specific antigen

Prostate-specific antigen (KLK3) is a protein from Homo sapiens identified by UniProt accession P07288, 261 residues long. MolForge cross-references it against 0 known binders and 595 disease associations.

Target properties

Protein name	Prostate-specific antigen
UniProt accession	P07288
Gene	KLK3
Organism	Homo sapiens
Length	261 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (595)

Diseases linked to this target (Open Targets).

prostate carcinoma · score 0.40
male reproductive organ cancer · score 0.24
benign prostatic hyperplasia · score 0.22
prostate cancer · score 0.22
cancer · score 0.22
cancer aggressiveness measurement · score 0.20
Gleason score measurement · score 0.20
neurodegenerative disease · score 0.19
abnormality of serum enzyme levels · score 0.19
cutaneous melanoma · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P07288-F1	alphafold	PREDICTED	91.88	—

Amino-acid sequence (261 residues)

MWVPVVFLTL SVTWIGAAPL ILSRIVGGWE CEKHSQPWQV LVASRGRAVC GGVLVHPQWV LTAAHCIRNK SVILLGRHSL FHPEDTGQVF QVSHSFPHPL YDMSLLKNRF LRPGDDSSHD LMLLRLSEPA ELTDAVKVMD LPTQEPALGT TCYASGWGSI EPEEFLTPKK LQCVDLHVIS NDVCAQVHPQ KVTKFMLCAG RWTGGKSTCS GDSGGPLVCN GVLQGITSWG SEPCALPERP SLYTKVVHYR KWIKDTIVAN P

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards