About Histone H1.0
Histone H1.0 (H1-0) is a protein
from Homo sapiens identified by UniProt accession
P07305, 194 residues long.
MolForge cross-references it against 0 known binders and
167 disease associations.
Target properties
| Protein name | Histone H1.0 |
|---|
| UniProt accession | P07305 |
|---|
| Gene | H1-0 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 194 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (167)
Diseases linked to this target (Open Targets).
- hip bone size · score 0.14
- erythrocyte count · score 0.13
- hip bone mineral density · score 0.11
- sex hormone-binding globulin measurement · score 0.08
- glaucoma · score 0.07
- intraocular pressure measurement · score 0.07
- cystatin C measurement · score 0.06
- idiopathic pulmonary arterial hypertension · score 0.05
- renal hypodysplasia/aplasia 3 · score 0.05
- Testicular regression syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07305-F1 | alphafold | PREDICTED | 68.73 | — |
Amino-acid sequence (194 residues)
MTENSTSAPA AKPKRAKASK KSTDHPKYSD MIVAAIQAEK NRAGSSRQSI QKYIKSHYKV GENADSQIKL SIKRLVTTGV LKQTKGVGAS GSFRLAKSDE PKKSVAFKKT KKEIKKVATP KKASKPKKAA SKAPTKKPKA TPVKKAKKKL AATPKKAKKP KTVKAKPVKA SKPKKAKPVK PKAKSSAKRA GKKK
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