Asialoglycoprotein receptor 1 (ASGR1)

About Asialoglycoprotein receptor 1

Asialoglycoprotein receptor 1 (ASGR1) is a protein from Homo sapiens identified by UniProt accession P07306, 291 residues long. MolForge cross-references it against 0 known binders and 208 disease associations.

Target properties

Protein name	Asialoglycoprotein receptor 1
UniProt accession	P07306
Gene	ASGR1
Organism	Homo sapiens
Length	291 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (5)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (208)

Diseases linked to this target (Open Targets).

alkaline phosphatase measurement · score 0.67
apolipoprotein B measurement · score 0.62
cholesteryl ester measurement · score 0.54
phospholipids:total lipids ratio · score 0.53
low density lipoprotein cholesterol measurement · score 0.53
concentration of large HDL particles measurement · score 0.52
high density lipoprotein particle size measurement · score 0.50
cholesterol in small HDL measurement · score 0.46
phospholipids in very large HDL measurement · score 0.41
phospholipids in medium LDL measurement · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P07306-F1	alphafold	PREDICTED	86.16	—

Amino-acid sequence (291 residues)

MTKEYQDLQH LDNEESDHHQ LRKGPPPPQP LLQRLCSGPR LLLLSLGLSL LLLVVVCVIG SQNSQLQEEL RGLRETFSNF TASTEAQVKG LSTQGGNVGR KMKSLESQLE KQQKDLSEDH SSLLLHVKQF VSDLRSLSCQ MAALQGNGSE RTCCPVNWVE HERSCYWFSR SGKAWADADN YCRLEDAHLV VVTSWEEQKF VQHHIGPVNT WMGLHDQNGP WKWVDGTDYE TGFKNWRPEQ PDDWYGHGLG GGEDCAHFTD DGRWNDDVCQ RPYRWVCETE LDKASQEPPL L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards