About Gamma-crystallin C
Gamma-crystallin C (CRYGC) is a protein
from Homo sapiens identified by UniProt accession
P07315, 174 residues long.
MolForge cross-references it against 0 known binders and
167 disease associations.
Target properties
| Protein name | Gamma-crystallin C |
|---|
| UniProt accession | P07315 |
|---|
| Gene | CRYGC |
|---|
| Organism | Homo sapiens |
|---|
| Length | 174 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (167)
Diseases linked to this target (Open Targets).
- pulverulent cataract · score 0.72
- early-onset non-syndromic cataract · score 0.70
- Autosomal dominant optic atrophy and cataract · score 0.50
- Developmental cataract · score 0.42
- Cataract-microcornea syndrome · score 0.40
- early-onset nuclear cataract · score 0.37
- genetic disorder · score 0.19
- daytime rest measurement · score 0.17
- lymphocyte count · score 0.14
- response to vaccine · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07315-F1 | alphafold | PREDICTED | 96.68 | — |
Amino-acid sequence (174 residues)
MGKITFYEDR AFQGRSYETT TDCPNLQPYF SRCNSIRVES GCWMLYERPN YQGQQYLLRR GEYPDYQQWM GLSDSIRSCC LIPQTVSHRL RLYEREDHKG LMMELSEDCP SIQDRFHLSE IRSLHVLEGC WVLYELPNYR GRQYLLRPQE YRRCQDWGAM DAKAGSLRRV VDLY
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