About Gamma-crystallin B
Gamma-crystallin B (CRYGB) is a protein
from Homo sapiens identified by UniProt accession
P07316, 175 residues long.
MolForge cross-references it against 0 known binders and
105 disease associations.
Target properties
| Protein name | Gamma-crystallin B |
|---|
| UniProt accession | P07316 |
|---|
| Gene | CRYGB |
|---|
| Organism | Homo sapiens |
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| Length | 175 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (105)
Diseases linked to this target (Open Targets).
- Total congenital cataract · score 0.50
- Anterior polar cataract · score 0.50
- early-onset non-syndromic cataract · score 0.43
- total early-onset cataract · score 0.37
- early-onset anterior polar cataract · score 0.37
- cataract · score 0.12
- Posterior polar cataract · score 0.12
- Cataract with Y-shaped suture opacities · score 0.11
- Partial congenital cataract · score 0.11
- Cataract-microcornea syndrome · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07316-F1 | alphafold | PREDICTED | 96.87 | — |
Amino-acid sequence (175 residues)
MGKITFYEDR AFQGRSYECT TDCPNLQPYF SRCNSIRVES GCWMIYERPN YQGHQYFLRR GEYPDYQQWM GLSDSIRSCC LIPPHSGAYR MKIYDRDELR GQMSELTDDC ISVQDRFHLT EIHSLNVLEG SWILYEMPNY RGRQYLLRPG EYRRFLDWGA PNAKVGSLRR VMDLY
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