About Gamma-crystallin D
Gamma-crystallin D (CRYGD) is a protein
from Homo sapiens identified by UniProt accession
P07320, 174 residues long.
MolForge cross-references it against 0 known binders and
219 disease associations.
Target properties
| Protein name | Gamma-crystallin D |
|---|
| UniProt accession | P07320 |
|---|
| Gene | CRYGD |
|---|
| Organism | Homo sapiens |
|---|
| Length | 174 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (219)
Diseases linked to this target (Open Targets).
- Cataract-microcornea syndrome · score 0.64
- cataract · score 0.56
- Autosomal dominant optic atrophy and cataract · score 0.47
- early-onset non-syndromic cataract · score 0.45
- Developmental cataract · score 0.42
- genetic disorder · score 0.40
- pulverulent cataract · score 0.39
- coralliform cataract · score 0.37
- Cataract · score 0.37
- cerulean cataract · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07320-F1 | alphafold | PREDICTED | 96.44 | — |
Amino-acid sequence (174 residues)
MGKITLYEDR GFQGRHYECS SDHPNLQPYL SRCNSARVDS GCWMLYEQPN YSGLQYFLRR GDYADHQQWM GLSDSVRSCR LIPHSGSHRI RLYEREDYRG QMIEFTEDCS CLQDRFRFNE IHSLNVLEGS WVLYELSNYR GRQYLLMPGD YRRYQDWGAT NARVGSLRRV IDFS
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