About Alcohol dehydrogenase 1A
Alcohol dehydrogenase 1A (ADH1A) is a protein
from Homo sapiens identified by UniProt accession
P07327, 375 residues long.
MolForge cross-references it against 0 known binders and
193 disease associations.
Target properties
| Protein name | Alcohol dehydrogenase 1A |
|---|
| UniProt accession | P07327 |
|---|
| Gene | ADH1A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 375 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (193)
Diseases linked to this target (Open Targets).
- vitamin D measurement · score 0.48
- glioblastoma multiforme · score 0.17
- alcohol dependence measurement · score 0.17
- cutaneous melanoma · score 0.16
- alcohol dependence · score 0.14
- lung adenocarcinoma · score 0.11
- urinary bladder cancer · score 0.11
- neoplasm · score 0.10
- hepatocellular carcinoma · score 0.10
- hemoglobin measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07327-F1 | alphafold | PREDICTED | 97.96 | — |
Amino-acid sequence (375 residues)
MSTAGKVIKC KAAVLWELKK PFSIEEVEVA PPKAHEVRIK MVAVGICGTD DHVVSGTMVT PLPVILGHEA AGIVESVGEG VTTVKPGDKV IPLAIPQCGK CRICKNPESN YCLKNDVSNP QGTLQDGTSR FTCRRKPIHH FLGISTFSQY TVVDENAVAK IDAASPLEKV CLIGCGFSTG YGSAVNVAKV TPGSTCAVFG LGGVGLSAIM GCKAAGAARI IAVDINKDKF AKAKELGATE CINPQDYKKP IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPDSQ NLSMNPMLLL TGRTWKGAIL GGFKSKECVP KLVADFMAKK FSLDALITHV LPFEKINEGF DLLHSGKSIR TILMF
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