About Cathepsin D
Cathepsin D (CTSD) is a protein
from Homo sapiens identified by UniProt accession
P07339, 412 residues long.
MolForge cross-references it against 0 known binders and
673 disease associations.
Target properties
| Protein name | Cathepsin D |
|---|
| UniProt accession | P07339 |
|---|
| Gene | CTSD |
|---|
| Organism | Homo sapiens |
|---|
| Length | 412 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (673)
Diseases linked to this target (Open Targets).
- CLN10 disease · score 0.77
- neuronal ceroid lipofuscinosis 10 · score 0.73
- neuronal ceroid lipofuscinosis · score 0.66
- Congenital neuronal ceroid lipofuscinosis · score 0.55
- neurodegenerative disease · score 0.50
- aspartate aminotransferase measurement · score 0.50
- blood protein measurement · score 0.42
- cathepsin D measurement · score 0.39
- lysosomal storage disease · score 0.37
- genetic disorder · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07339-F1 | alphafold | PREDICTED | 84.99 | — |
Amino-acid sequence (412 residues)
MQPSSLLPLA LCLLAAPASA LVRIPLHKFT SIRRTMSEVG GSVEDLIAKG PVSKYSQAVP AVTEGPIPEV LKNYMDAQYY GEIGIGTPPQ CFTVVFDTGS SNLWVPSIHC KLLDIACWIH HKYNSDKSST YVKNGTSFDI HYGSGSLSGY LSQDTVSVPC QSASSASALG GVKVERQVFG EATKQPGITF IAAKFDGILG MAYPRISVNN VLPVFDNLMQ QKLVDQNIFS FYLSRDPDAQ PGGELMLGGT DSKYYKGSLS YLNVTRKAYW QVHLDQVEVA SGLTLCKEGC EAIVDTGTSL MVGPVDEVRE LQKAIGAVPL IQGEYMIPCE KVSTLPAITL KLGGKGYKLS PEDYTLKVSQ AGKTLCLSGF MGMDIPPPSG PLWILGDVFI GRYYTVFDRD NNRVGFAEAA RL
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