About Annexin A2
Annexin A2 (ANXA2) is a protein
from Homo sapiens identified by UniProt accession
P07355, 339 residues long.
MolForge cross-references it against 0 known binders and
503 disease associations.
Target properties
| Protein name | Annexin A2 |
|---|
| UniProt accession | P07355 |
|---|
| Gene | ANXA2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 339 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (503)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- blood protein measurement · score 0.35
- arterial stiffness measurement · score 0.30
- Parkinson disease · score 0.29
- multiple sclerosis · score 0.29
- lysosomal storage disease · score 0.29
- Alzheimer disease · score 0.29
- age at first facial hair · score 0.28
- PHF-tau measurement · score 0.19
- age at voice drop · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07355-F1 | alphafold | PREDICTED | 94.25 | — |
Amino-acid sequence (339 residues)
MSTVHEILCK LSLEGDHSTP PSAYGSVKAY TNFDAERDAL NIETAIKTKG VDEVTIVNIL TNRSNAQRQD IAFAYQRRTK KELASALKSA LSGHLETVIL GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM YKTDLEKDII SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDARDLYD AGVKRKGTDV PKWISIMTER SVPHLQKVFD RYKSYSPYDM LESIRKEVKG DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD
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