About Complement component C8 alpha chain
Complement component C8 alpha chain (C8A) is a protein
from Homo sapiens identified by UniProt accession
P07357, 584 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | Complement component C8 alpha chain |
|---|
| UniProt accession | P07357 |
|---|
| Gene | C8A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 584 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (44)
Diseases linked to this target (Open Targets).
- Immunodeficiency due to a late component of complements deficiency · score 0.62
- blood protein measurement · score 0.39
- immunodeficiency due to a late component of complement deficiency · score 0.37
- lung adenocarcinoma · score 0.18
- cutaneous melanoma · score 0.18
- head and neck squamous cell carcinoma · score 0.17
- white matter microstructure measurement · score 0.13
- squamous cell lung carcinoma · score 0.12
- C-C motif chemokine 1 measurement · score 0.04
- neurexophilin-1 measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07357-F1 | alphafold | PREDICTED | 78.68 | — |
Amino-acid sequence (584 residues)
MFAVVFFILS LMTCQPGVTA QEKVNQRVRR AATPAAVTCQ LSNWSEWTDC FPCQDKKYRH RSLLQPNKFG GTICSGDIWD QASCSSSTTC VRQAQCGQDF QCKETGRCLK RHLVCNGDQD CLDGSDEDDC EDVRAIDEDC SQYEPIPGSQ KAALGYNILT QEDAQSVYDA SYYGGQCETV YNGEWRELRY DSTCERLYYG DDEKYFRKPY NFLKYHFEAL ADTGISSEFY DNANDLLSKV KKDKSDSFGV TIGIGPAGSP LLVGVGVSHS QDTSFLNELN KYNEKKFIFT RIFTKVQTAH FKMRKDDIML DEGMLQSLME LPDQYNYGMY AKFINDYGTH YITSGSMGGI YEYILVIDKA KMESLGITSR DITTCFGGSL GIQYEDKINV GGGLSGDHCK KFGGGKTERA RKAMAVEDII SRVRGGSSGW SGGLAQNRST ITYRSWGRSL KYNPVVIDFE MQPIHEVLRH TSLGPLEAKR QNLRRALDQY LMEFNACRCG PCFNNGVPIL EGTSCRCQCR LGSLGAACEQ TQTEGAKADG SWSCWSSWSV CRAGIQERRR ECDNPAPQNG GASCPGRKVQ TQAC
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