About Complement component C8 beta chain
Complement component C8 beta chain (C8B) is a protein
from Homo sapiens identified by UniProt accession
P07358, 591 residues long.
MolForge cross-references it against 0 known binders and
98 disease associations.
Target properties
| Protein name | Complement component C8 beta chain |
|---|
| UniProt accession | P07358 |
|---|
| Gene | C8B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 591 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (98)
Diseases linked to this target (Open Targets).
- type II complement component 8 deficiency · score 0.67
- Immunodeficiency due to a late component of complements deficiency · score 0.54
- blood protein measurement · score 0.49
- neurexophilin-1 measurement · score 0.42
- complement component C8 measurement · score 0.39
- gut microbiome measurement · score 0.38
- immunodeficiency due to a late component of complement deficiency · score 0.37
- white matter microstructure measurement · score 0.30
- C-C motif chemokine 1 measurement · score 0.30
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07358-F1 | alphafold | PREDICTED | 81.55 | — |
Amino-acid sequence (591 residues)
MKNSRTWAWR APVELFLLCA ALGCLSLPGS RGERPHSFGS NAVNKSFAKS RQMRSVDVTL MPIDCELSSW SSWTTCDPCQ KKRYRYAYLL QPSQFHGEPC NFSDKEVEDC VTNRPCGSQV RCEGFVCAQT GRCVNRRLLC NGDNDCGDQS DEANCRRIYK KCQHEMDQYW GIGSLASGIN LFTNSFEGPV LDHRYYAGGC SPHYILNTRF RKPYNVESYT PQTQGKYEFI LKEYESYSDF ERNVTEKMAS KSGFSFGFKI PGIFELGISS QSDRGKHYIR RTKRFSHTKS VFLHARSDLE VAHYKLKPRS LMLHYEFLQR VKRLPLEYSY GEYRDLFRDF GTHYITEAVL GGIYEYTLVM NKEAMERGDY TLNNVHACAK NDFKIGGAIE EVYVSLGVSV GKCRGILNEI KDRNKRDTMV EDLVVLVRGG ASEHITTLAY QELPTADLMQ EWGDAVQYNP AIIKVKVEPL YELVTATDFA YSSTVRQNMK QALEEFQKEV SSCHCAPCQG NGVPVLKGSR CDCICPVGSQ GLACEVSYRK NTPIDGKWNC WSNWSSCSGR RKTRQRQCNN PPPQNGGSPC SGPASETLDC S
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