About Platelet glycoprotein Ib alpha chain
Platelet glycoprotein Ib alpha chain (GP1BA) is a protein
from Homo sapiens identified by UniProt accession
P07359, 652 residues long.
MolForge cross-references it against 0 known binders and
302 disease associations.
Target properties
| Protein name | Platelet glycoprotein Ib alpha chain |
|---|
| UniProt accession | P07359 |
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| Gene | GP1BA |
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| Organism | Homo sapiens |
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| Length | 652 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (302)
Diseases linked to this target (Open Targets).
- Bernard-Soulier syndrome · score 0.81
- platelet-type von Willebrand disease · score 0.77
- platelet count · score 0.67
- mean platelet volume · score 0.67
- platelet component distribution width · score 0.66
- Macrothrombocytopenia · score 0.47
- Optic neuropathy · score 0.43
- Thrombocytopenia · score 0.42
- autosomal dominant macrothrombocytopenia · score 0.39
- platelet crit · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07359-F1 | alphafold | PREDICTED | 64.33 | — |
Amino-acid sequence (652 residues)
MPLLLLLLLL PSPLHPHPIC EVSKVASHLE VNCDKRNLTA LPPDLPKDTT ILHLSENLLY TFSLATLMPY TRLTQLNLDR CELTKLQVDG TLPVLGTLDL SHNQLQSLPL LGQTLPALTV LDVSFNRLTS LPLGALRGLG ELQELYLKGN ELKTLPPGLL TPTPKLEKLS LANNNLTELP AGLLNGLENL DTLLLQENSL YTIPKGFFGS HLLPFAFLHG NPWLCNCEIL YFRRWLQDNA ENVYVWKQGV DVKAMTSNVA SVQCDNSDKF PVYKYPGKGC PTLGDEGDTD LYDYYPEEDT EGDKVRATRT VVKFPTKAHT TPWGLFYSWS TASLDSQMPS SLHPTQESTK EQTTFPPRWT PNFTLHMESI TFSKTPKSTT EPTPSPTTSE PVPEPAPNMT TLEPTPSPTT PEPTSEPAPS PTTPEPTSEP APSPTTPEPT SEPAPSPTTP EPTPIPTIAT SPTILVSATS LITPKSTFLT TTKPVSLLES TKKTIPELDQ PPKLRGVLQG HLESSRNDPF LHPDFCCLLP LGFYVLGLFW LLFASVVLIL LLSWVGHVKP QALDSGQGAA LTTATQTTHL ELQRGRQVTV PRAWLLFLRG SLPTFRSSLF LWVRPNGRVG PLVAGRRPSA LSQGRGQDLL STVSIRYSGH SL
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