About Complement component C8 gamma chain
Complement component C8 gamma chain (C8G) is a protein
from Homo sapiens identified by UniProt accession
P07360, 202 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | Complement component C8 gamma chain |
|---|
| UniProt accession | P07360 |
|---|
| Gene | C8G |
|---|
| Organism | Homo sapiens |
|---|
| Length | 202 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (42)
Diseases linked to this target (Open Targets).
- immunodeficiency due to a late component of complement deficiency · score 0.37
- blood protein measurement · score 0.33
- platelet count · score 0.21
- platelet crit · score 0.19
- cutaneous melanoma · score 0.18
- head and neck squamous cell carcinoma · score 0.17
- Immunodeficiency · score 0.15
- hemoglobin measurement · score 0.11
- intraocular pressure measurement · score 0.06
- central corneal thickness · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07360-F1 | alphafold | PREDICTED | 89.74 | — |
Amino-acid sequence (202 residues)
MLPPGTATLL TLLLAAGSLG QKPQRPRRPA SPISTIQPKA NFDAQQFAGT WLLVAVGSAC RFLQEQGHRA EATTLHVAPQ GTAMAVSTFR KLDGICWQVR QLYGDTGVLG RFLLQARDAR GAVHVVVAET DYQSFAVLYL ERAGQLSVKL YARSLPVSDS VLSGFEQRVQ EAHLTEDQIF YFPKYGFCEA ADQFHVLDEV RR
Explore Complement component C8 gamma chain with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets