About Calpain-1 catalytic subunit
Calpain-1 catalytic subunit (CAPN1) is a protein
from Homo sapiens identified by UniProt accession
P07384, 714 residues long.
MolForge cross-references it against 0 known binders and
294 disease associations.
Target properties
| Protein name | Calpain-1 catalytic subunit |
|---|
| UniProt accession | P07384 |
|---|
| Gene | CAPN1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 714 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (294)
Diseases linked to this target (Open Targets).
- Autosomal recessive spastic paraplegia type 76 · score 0.77
- Alzheimer disease · score 0.37
- neurodegenerative disease · score 0.32
- urate measurement · score 0.30
- high density lipoprotein cholesterol measurement · score 0.30
- breast adenocarcinoma · score 0.26
- glioblastoma multiforme · score 0.23
- genetic disorder · score 0.19
- head and neck squamous cell carcinoma · score 0.19
- clear cell renal carcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07384-F1 | alphafold | PREDICTED | 89.92 | — |
Amino-acid sequence (714 residues)
MSEEIITPVY CTGVSAQVQK QRARELGLGR HENAIKYLGQ DYEQLRVRCL QSGTLFRDEA FPPVPQSLGY KDLGPNSSKT YGIKWKRPTE LLSNPQFIVD GATRTDICQG ALGDCWLLAA IASLTLNDTL LHRVVPHGQS FQNGYAGIFH FQLWQFGEWV DVVVDDLLPI KDGKLVFVHS AEGNEFWSAL LEKAYAKVNG SYEALSGGST SEGFEDFTGG VTEWYELRKA PSDLYQIILK ALERGSLLGC SIDISSVLDM EAITFKKLVK GHAYSVTGAK QVNYRGQVVS LIRMRNPWGE VEWTGAWSDS SSEWNNVDPY ERDQLRVKME DGEFWMSFRD FMREFTRLEI CNLTPDALKS RTIRKWNTTL YEGTWRRGST AGGCRNYPAT FWVNPQFKIR LDETDDPDDY GDRESGCSFV LALMQKHRRR ERRFGRDMET IGFAVYEVPP ELVGQPAVHL KRDFFLANAS RARSEQFINL REVSTRFRLP PGEYVVVPST FEPNKEGDFV LRFFSEKSAG TVELDDQIQA NLPDEQVLSE EEIDENFKAL FRQLAGEDME ISVKELRTIL NRIISKHKDL RTKGFSLESC RSMVNLMDRD GNGKLGLVEF NILWNRIRNY LSIFRKFDLD KSGSMSAYEM RMAIESAGFK LNKKLYELII TRYSEPDLAV DFDNFVCCLV RLETMFRFFK TLDTDLDGVV TFDLFKWLQL TMFA
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