About Tubulin beta chain
Tubulin beta chain (TUBB) is a protein
from Homo sapiens identified by UniProt accession
P07437, 444 residues long.
MolForge cross-references it against 0 known binders and
586 disease associations.
Target properties
| Protein name | Tubulin beta chain |
|---|
| UniProt accession | P07437 |
|---|
| Gene | TUBB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 444 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (586)
Diseases linked to this target (Open Targets).
- multiple benign circumferential skin creases on limbs 1 · score 0.71
- Genetic central nervous system malformation · score 0.71
- complex cortical dysplasia with other brain malformations 6 · score 0.67
- non-small cell lung carcinoma · score 0.61
- multiple benign circumferential skin creases on limbs · score 0.61
- breast cancer · score 0.61
- breast carcinoma · score 0.60
- neoplasm · score 0.60
- breast neoplasm · score 0.60
- acute lymphoblastic leukemia · score 0.59
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07437-F1 | alphafold | PREDICTED | 92.08 | — |
Amino-acid sequence (444 residues)
MREIVHIQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLDRISVY YNEATGGKYV PRAILVDLEP GTMDSVRSGP FGQIFRPDNF VFGQSGAGNN WAKGHYTEGA ELVDSVLDVV RKEAESCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEYP DRIMNTFSVV PSPKVSDTVV EPYNATLSVH QLVENTDETY CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTCL RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQVFDAKNMM AACDPRHGRY LTVAAVFRGR MSMKEVDEQM LNVQNKNSSY FVEWIPNNVK TAVCDIPPRG LKMAVTFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS EYQQYQDATA EEEEDFGEEA EEEA
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