About Trypsin-2
Trypsin-2 (PRSS2) is a protein
from Homo sapiens identified by UniProt accession
P07478, 247 residues long.
MolForge cross-references it against 0 known binders and
188 disease associations.
Target properties
| Protein name | Trypsin-2 |
|---|
| UniProt accession | P07478 |
|---|
| Gene | PRSS2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 247 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (188)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.24
- alcoholic pancreatitis · score 0.23
- trypsin-2 measurement · score 0.23
- pancreatitis · score 0.21
- neuroinflammatory disorder · score 0.18
- neoplasm · score 0.08
- Gorham-Stout disease · score 0.07
- Familial short QT syndrome · score 0.06
- Romano-Ward syndrome · score 0.06
- familial atrial fibrillation · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07478-F1 | alphafold | PREDICTED | 92.06 | — |
Amino-acid sequence (247 residues)
MNLLLILTFV AAAVAAPFDD DDKIVGGYIC EENSVPYQVS LNSGYHFCGG SLISEQWVVS AGHCYKSRIQ VRLGEHNIEV LEGNEQFINA AKIIRHPKYN SRTLDNDILL IKLSSPAVIN SRVSAISLPT APPAAGTESL ISGWGNTLSS GADYPDELQC LDAPVLSQAE CEASYPGKIT NNMFCVGFLE GGKDSCQGDS GGPVVSNGEL QGIVSWGYGC AQKNRPGVYT KVYNYVDWIK DTIAANS
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