Gastrin-releasing peptide (GRP)

About Gastrin-releasing peptide

Gastrin-releasing peptide (GRP) is a protein from Homo sapiens identified by UniProt accession P07492, 148 residues long. MolForge cross-references it against 0 known binders and 317 disease associations.

Target properties

Protein name	Gastrin-releasing peptide
UniProt accession	P07492
Gene	GRP
Organism	Homo sapiens
Length	148 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (317)

Diseases linked to this target (Open Targets).

body mass index · score 0.44
lean body mass · score 0.36
type 2 diabetes mellitus · score 0.36
fat body mass · score 0.32
body weight · score 0.29
smoking behavior · score 0.27
appendicular lean mass · score 0.27
pancreatic carcinoma · score 0.25
breast adenocarcinoma · score 0.25
body height · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P07492-F1	alphafold	PREDICTED	63.95	—

Amino-acid sequence (148 residues)

MRGRELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM GKKSTGESSS VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ PKALGNQQPS WDSEDSSNFK DVGSKGKVGR LSAPGSQREG RNPQLNQQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards