About Acetylcholine receptor subunit gamma
Acetylcholine receptor subunit gamma (CHRNG) is a protein
from Homo sapiens identified by UniProt accession
P07510, 517 residues long.
MolForge cross-references it against 0 known binders and
136 disease associations.
Target properties
| Protein name | Acetylcholine receptor subunit gamma |
|---|
| UniProt accession | P07510 |
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| Gene | CHRNG |
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| Organism | Homo sapiens |
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| Length | 517 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (136)
Diseases linked to this target (Open Targets).
- autosomal recessive multiple pterygium syndrome · score 0.80
- lethal multiple pterygium syndrome · score 0.77
- post-operative sign or symptom · score 0.58
- pain · score 0.55
- acute respiratory distress syndrome · score 0.53
- pregnancy · score 0.50
- severe acute respiratory syndrome · score 0.50
- genetic disorder · score 0.49
- morbid obesity · score 0.46
- rotator cuff tear · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07510-F1 | alphafold | PREDICTED | 81.27 | — |
Amino-acid sequence (517 residues)
MHGGQGPLLL LLLLAVCLGA QGRNQEERLL ADLMQNYDPN LRPAERDSDV VNVSLKLTLT NLISLNEREE ALTTNVWIEM QWCDYRLRWD PRDYEGLWVL RVPSTMVWRP DIVLENNVDG VFEVALYCNV LVSPDGCIYW LPPAIFRSAC SISVTYFPFD WQNCSLIFQS QTYSTNEIDL QLSQEDGQTI EWIFIDPEAF TENGEWAIQH RPAKMLLDPA APAQEAGHQK VVFYLLIQRK PLFYVINIIA PCVLISSVAI LIHFLPAKAG GQKCTVAINV LLAQTVFLFL VAKKVPETSQ AVPLISKYLT FLLVVTILIV VNAVVVLNVS LRSPHTHSMA RGVRKVFLRL LPQLLRMHVR PLAPAAVQDT QSRLQNGSSG WSITTGEEVA LCLPRSELLF QQWQRQGLVA AALEKLEKGP ELGLSQFCGS LKQAAPAIQA CVEACNLIAC ARHQQSHFDN GNEEWFLVGR VLDRVCFLAM LSLFICGTAG IFLMAHYNRV PALPFPGDPR PYLPSPD
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