Decorin (DCN)

About Decorin

Decorin (DCN) is a protein from Homo sapiens identified by UniProt accession P07585, 359 residues long. MolForge cross-references it against 0 known binders and 542 disease associations.

Target properties

Protein name	Decorin
UniProt accession	P07585
Gene	DCN
Organism	Homo sapiens
Length	359 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (542)

Diseases linked to this target (Open Targets).

congenital stromal corneal dystrophy · score 0.69
refractive error measurement · score 0.38
blood protein measurement · score 0.32
central corneal thickness · score 0.30
neurofibrillary tangles measurement · score 0.29
Abnormality of refraction · score 0.25
refractive error · score 0.24
alcohol consumption measurement · score 0.20
cutaneous melanoma · score 0.20
genetic disorder · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P07585-F1	alphafold	PREDICTED	88.63	—

Amino-acid sequence (359 residues)

MKATIILLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPEV PDDRDFEPSL GPVCPFRCQC HLRVVQCSDL GLDKVPKDLP PDTTLLDLQN NKITEIKDGD FKNLKNLHAL ILVNNKISKV SPGAFTPLVK LERLYLSKNQ LKELPEKMPK TLQELRAHEN EITKVRKVTF NGLNQMIVIE LGTNPLKSSG IENGAFQGMK KLSYIRIADT NITSIPQGLP PSLTELHLDG NKISRVDAAS LKGLNNLAKL GLSFNSISAV DNGSLANTPH LRELHLDNNK LTRVPGGLAE HKYIQVVYLH NNNISVVGSS DFCPPGHNTK KASYSGVSLF SNPVQYWEIQ PSTFRCVYVR SAIQLGNYK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards