Prosaposin (PSAP)

About Prosaposin

Prosaposin (PSAP) is a protein from Homo sapiens identified by UniProt accession P07602, 524 residues long. MolForge cross-references it against 0 known binders and 509 disease associations.

Target properties

Protein name	Prosaposin
UniProt accession	P07602
Gene	PSAP
Organism	Homo sapiens
Length	524 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (509)

Diseases linked to this target (Open Targets).

Gaucher disease due to saposin C deficiency · score 0.79
combined PSAP deficiency · score 0.78
Krabbe disease due to saposin A deficiency · score 0.77
Parkinson disease · score 0.61
metachromatic leukodystrophy · score 0.58
neurodegenerative disease · score 0.57
lysosomal storage disease · score 0.54
Alzheimer disease · score 0.53
multiple sclerosis · score 0.53
Krabbe disease · score 0.51

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P07602-F1	alphafold	PREDICTED	73.75	—

Amino-acid sequence (524 residues)

MYALFLLASL LGAALAGPVL GLKECTRGSA VWCQNVKTAS DCGAVKHCLQ TVWNKPTVKS LPCDICKDVV TAAGDMLKDN ATEEEILVYL EKTCDWLPKP NMSASCKEIV DSYLPVILDI IKGEMSRPGE VCSALNLCES LQKHLAELNH QKQLESNKIP ELDMTEVVAP FMANIPLLLY PQDGPRSKPQ PKDNGDVCQD CIQMVTDIQT AVRTNSTFVQ ALVEHVKEEC DRLGPGMADI CKNYISQYSE IAIQMMMHMQ PKEICALVGF CDEVKEMPMQ TLVPAKVASK NVIPALELVE PIKKHEVPAK SDVYCEVCEF LVKEVTKLID NNKTEKEILD AFDKMCSKLP KSLSEECQEV VDTYGSSILS ILLEEVSPEL VCSMLHLCSG TRLPALTVHV TQPKDGGFCE VCKKLVGYLD RNLEKNSTKQ EILAALEKGC SFLPDPYQKQ CDQFVAEYEP VLIEILVEVM DPSFVCLKIG ACPSAHKPLL GTEKCIWGPS YWCQNTETAA QCNAVEHCKR HVWN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards