About Beta-hexosaminidase subunit beta
Beta-hexosaminidase subunit beta (HEXB) is a protein
from Homo sapiens identified by UniProt accession
P07686, 556 residues long.
MolForge cross-references it against 0 known binders and
264 disease associations.
Target properties
| Protein name | Beta-hexosaminidase subunit beta |
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| UniProt accession | P07686 |
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| Gene | HEXB |
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| Organism | Homo sapiens |
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| Length | 556 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (264)
Diseases linked to this target (Open Targets).
- Sandhoff disease · score 0.84
- Sandhoff disease, infantile form · score 0.57
- Sandhoff disease, adult form · score 0.55
- Sandhoff disease, juvenile form · score 0.55
- GM2 gangliosidosis · score 0.51
- genetic disorder · score 0.49
- neurodegenerative disease · score 0.39
- cortical surface area measurement · score 0.36
- Parkinson disease · score 0.30
- Alzheimer disease · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07686-F1 | alphafold | PREDICTED | 92.83 | — |
Amino-acid sequence (556 residues)
MELCGLGLPR PPMLLALLLA TLLAAMLALL TQVALVVQVA EAARAPSVSA KPGPALWPLP LLVKMTPNLL HLAPENFYIS HSPNSTAGPS CTLLEEAFRR YHGYIFGFYK WHHEPAEFQA KTQVQQLLVS ITLQSECDAF PNISSDESYT LLVKEPVAVL KANRVWGALR GLETFSQLVY QDSYGTFTIN ESTIIDSPRF SHRGILIDTS RHYLPVKIIL KTLDAMAFNK FNVLHWHIVD DQSFPYQSIT FPELSNKGSY SLSHVYTPND VRMVIEYARL RGIRVLPEFD TPGHTLSWGK GQKDLLTPCY SRQNKLDSFG PINPTLNTTY SFLTTFFKEI SEVFPDQFIH LGGDEVEFKC WESNPKIQDF MRQKGFGTDF KKLESFYIQK VLDIIATINK GSIVWQEVFD DKAKLAPGTI VEVWKDSAYP EELSRVTASG FPVILSAPWY LDLISYGQDW RKYYKVEPLD FGGTQKQKQL FIGGEACLWG EYVDATNLTP RLWPRASAVG ERLWSSKDVR DMDDAYDRLT RHRCRMVERG IAAQPLYAGY CNHENM
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