About Profilin-1
Profilin-1 (PFN1) is a protein
from Homo sapiens identified by UniProt accession
P07737, 140 residues long.
MolForge cross-references it against 0 known binders and
213 disease associations.
Target properties
| Protein name | Profilin-1 |
|---|
| UniProt accession | P07737 |
|---|
| Gene | PFN1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 140 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (213)
Diseases linked to this target (Open Targets).
- amyotrophic lateral sclerosis type 18 · score 0.74
- familial amyotrophic lateral sclerosis · score 0.54
- neurodegenerative disease · score 0.48
- amyotrophic lateral sclerosis · score 0.41
- Amyotrophic lateral sclerosis · score 0.37
- mean platelet volume · score 0.37
- neuroinflammatory disorder · score 0.37
- Neurodegeneration · score 0.27
- Lower limb muscle weakness · score 0.26
- breast adenocarcinoma · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07737-F1 | alphafold | PREDICTED | 95.59 | — |
Amino-acid sequence (140 residues)
MAGWNAYIDN LMADGTCQDA AIVGYKDSPS VWAAVPGKTF VNITPAEVGV LVGKDRSSFY VNGLTLGGQK CSVIRDSLLQ DGEFSMDLRT KSTGGAPTFN VTVTKTDKTL VLLMGKEGVH GGLINKKCYE MASHLRRSQY
Explore Profilin-1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets