Bisphosphoglycerate mutase (BPGM)

About Bisphosphoglycerate mutase

Bisphosphoglycerate mutase (BPGM) is a protein from Homo sapiens identified by UniProt accession P07738, 259 residues long. MolForge cross-references it against 0 known binders and 179 disease associations.

Target properties

Protein name	Bisphosphoglycerate mutase
UniProt accession	P07738
Gene	BPGM
Organism	Homo sapiens
Length	259 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (179)

Diseases linked to this target (Open Targets).

hemolytic anemia due to diphosphoglycerate mutase deficiency · score 0.68
autosomal recessive secondary polycythemia not associated with VHL gene · score 0.37
reticulocyte count · score 0.29
lymphocyte count · score 0.28
leukocyte count · score 0.27
Immature Reticulocyte Fraction Measurement · score 0.24
monocyte count · score 0.24
reticulocyte measurement · score 0.22
myeloid white cell count · score 0.20
mean reticulocyte volume · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P07738-F1	alphafold	PREDICTED	95.73	—

Amino-acid sequence (259 residues)

MSKYKLIMLR HGEGAWNKEN RFCSWVDQKL NSEGMEEARN CGKQLKALNF EFDLVFTSVL NRSIHTAWLI LEELGQEWVP VESSWRLNER HYGALIGLNR EQMALNHGEE QVRLWRRSYN VTPPPIEESH PYYQEIYNDR RYKVCDVPLD QLPRSESLKD VLERLLPYWN ERIAPEVLRG KTILISAHGN SSRALLKHLE GISDEDIINI TLPTGVPILL ELDENLRAVG PHQFLGDQEA IQAAIKKVED QGKVKQAKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards