About Adenine phosphoribosyltransferase
Adenine phosphoribosyltransferase (APRT) is a protein
from Homo sapiens identified by UniProt accession
P07741, 180 residues long.
MolForge cross-references it against 0 known binders and
263 disease associations.
Target properties
| Protein name | Adenine phosphoribosyltransferase |
|---|
| UniProt accession | P07741 |
|---|
| Gene | APRT |
|---|
| Organism | Homo sapiens |
|---|
| Length | 180 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (263)
Diseases linked to this target (Open Targets).
- adenine phosphoribosyltransferase deficiency · score 0.81
- neurodegenerative disease · score 0.40
- HbA1c measurement · score 0.28
- chronic kidney disease · score 0.24
- hemoglobin measurement · score 0.24
- interstitial nephritis · score 0.19
- stage 5 chronic kidney disease · score 0.18
- genetic disorder · score 0.18
- mean corpuscular hemoglobin concentration · score 0.16
- reticulocyte count · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07741-F1 | alphafold | PREDICTED | 96.91 | — |
Amino-acid sequence (180 residues)
MADSELQLVE QRIRSFPDFP TPGVVFRDIS PVLKDPASFR AAIGLLARHL KATHGGRIDY IAGLDSRGFL FGPSLAQELG LGCVLIRKRG KLPGPTLWAS YSLEYGKAEL EIQKDALEPG QRVVVVDDLL ATGGTMNAAC ELLGRLQAEV LECVSLVELT SLKGREKLAP VPFFSLLQYE
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