T-cell surface glycoprotein CD3 epsilon chain (CD3E)

About T-cell surface glycoprotein CD3 epsilon chain

T-cell surface glycoprotein CD3 epsilon chain (CD3E) is a protein from Homo sapiens identified by UniProt accession P07766, 207 residues long. MolForge cross-references it against 0 known binders and 327 disease associations.

Target properties

Protein name	T-cell surface glycoprotein CD3 epsilon chain
UniProt accession	P07766
Gene	CD3E
Organism	Homo sapiens
Length	207 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (327)

Diseases linked to this target (Open Targets).

immunodeficiency 18 · score 0.74
multiple myeloma · score 0.58
follicular lymphoma · score 0.54
acute lymphoblastic leukemia · score 0.54
diffuse large B-cell lymphoma · score 0.54
type 1 diabetes mellitus · score 0.53
lymphoid leukemia · score 0.51
neoplasm · score 0.50
T-B+ severe combined immunodeficiency · score 0.46
leukemia · score 0.45

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P07766-F1	alphafold	PREDICTED	73.07	—

Amino-acid sequence (207 residues)

MQSGTHWRVL GLCLLSVGVW GQDGNEEMGG ITQTPYKVSI SGTTVILTCP QYPGSEILWQ HNDKNIGGDE DDKNIGSDED HLSLKEFSEL EQSGYYVCYP RGSKPEDANF YLYLRARVCE NCMEMDVMSV ATIVIVDICI TGGLLLLVYY WSKNRKAKAK PVTRGAGAGG RQRGQNKERP PPVPNPDYEP IRKGQRDLYS GLNQRRI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards