About Cathepsin B
Cathepsin B (CTSB) is a protein
from Homo sapiens identified by UniProt accession
P07858, 339 residues long.
MolForge cross-references it against 0 known binders and
835 disease associations.
Target properties
| Protein name | Cathepsin B |
|---|
| UniProt accession | P07858 |
|---|
| Gene | CTSB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 339 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (835)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.45
- keratolytic winter erythema · score 0.37
- basophil count · score 0.35
- triglyceride measurement · score 0.34
- Parkinson disease · score 0.32
- neurodegenerative disease · score 0.31
- total cholesterol measurement · score 0.28
- risk-taking behaviour · score 0.27
- squalene synthase deficiency · score 0.27
- basophil percentage of leukocytes · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07858-F1 | alphafold | PREDICTED | 92.14 | — |
Amino-acid sequence (339 residues)
MWQLWASLCC LLVLANARSR PSFHPLSDEL VNYVNKRNTT WQAGHNFYNV DMSYLKRLCG TFLGGPKPPQ RVMFTEDLKL PASFDAREQW PQCPTIKEIR DQGSCGSCWA FGAVEAISDR ICIHTNAHVS VEVSAEDLLT CCGSMCGDGC NGGYPAEAWN FWTRKGLVSG GLYESHVGCR PYSIPPCEHH VNGSRPPCTG EGDTPKCSKI CEPGYSPTYK QDKHYGYNSY SVSNSEKDIM AEIYKNGPVE GAFSVYSDFL LYKSGVYQHV TGEMMGGHAI RILGWGVENG TPYWLVANSW NTDWGDNGFF KILRGQDHCG IESEVVAGIP RTDQYWEKI
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