L-lactate dehydrogenase C chain (LDHC)

About L-lactate dehydrogenase C chain

L-lactate dehydrogenase C chain (LDHC) is a protein from Homo sapiens identified by UniProt accession P07864, 332 residues long. MolForge cross-references it against 0 known binders and 159 disease associations.

Target properties

Protein name	L-lactate dehydrogenase C chain
UniProt accession	P07864
Gene	LDHC
Organism	Homo sapiens
Length	332 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (159)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.34
serum amyloid A-1 protein measurement · score 0.18
azoospermia · score 0.08
lung adenocarcinoma · score 0.08
hepatocellular carcinoma · score 0.08
male infertility with teratozoospermia due to single gene mutation · score 0.08
partial chromosome Y deletion · score 0.06
spermatogenic failure 3 · score 0.06
spermatogenic failure 55 · score 0.06
Rare genetic female infertility · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P07864-F1	alphafold	PREDICTED	96.37	—

Amino-acid sequence (332 residues)

MSTVKEQLIE KLIEDDENSQ CKITIVGTGA VGMACAISIL LKDLADELAL VDVALDKLKG EMMDLQHGSL FFSTSKITSG KDYSVSANSR IVIVTAGARQ QEGETRLALV QRNVAIMKSI IPAIVHYSPD CKILVVSNPV DILTYIVWKI SGLPVTRVIG SGCNLDSARF RYLIGEKLGV HPTSCHGWII GEHGDSSVPL WSGVNVAGVA LKTLDPKLGT DSDKEHWKNI HKQVIQSAYE IIKLKGYTSW AIGLSVMDLV GSILKNLRRV HPVSTMVKGL YGIKEELFLS IPCVLGRNGV SDVVKINLNS EEEALFKKSA ETLWNIQKDL IF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards