Galactose-1-phosphate uridylyltransferase (GALT)

About Galactose-1-phosphate uridylyltransferase

Galactose-1-phosphate uridylyltransferase (GALT) is a protein from Homo sapiens identified by UniProt accession P07902, 379 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.

Target properties

Protein name	Galactose-1-phosphate uridylyltransferase
UniProt accession	P07902
Gene	GALT
Organism	Homo sapiens
Length	379 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (63)

Diseases linked to this target (Open Targets).

classic galactosemia · score 0.81
galactosemia · score 0.79
genetic disorder · score 0.51
Cataract · score 0.46
Intellectual disability · score 0.46
primary ovarian insufficiency · score 0.34
blood protein measurement · score 0.32
interleukin-11 receptor subunit alpha measurement · score 0.21
chemokine (C-C motif) ligand 27 measurement · score 0.20
MODY · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P07902-F1	alphafold	PREDICTED	91.68	—

Amino-acid sequence (379 residues)

MSRSGTDPQQ RQQASEADAA AATFRANDHQ HIRYNPLQDE WVLVSAHRMK RPWQGQVEPQ LLKTVPRHDP LNPLCPGAIR ANGEVNPQYD STFLFDNDFP ALQPDAPSPG PSDHPLFQAK SARGVCKVMC FHPWSDVTLP LMSVPEIRAV VDAWASVTEE LGAQYPWVQI FENKGAMMGC SNPHPHCQVW ASSFLPDIAQ REERSQQAYK SQHGEPLLME YSRQELLRKE RLVLTSEHWL VLVPFWATWP YQTLLLPRRH VRRLPELTPA ERDDLASIMK KLLTKYDNLF ETSFPYSMGW HGAPTGSEAG ANWNHWQLHA HYYPPLLRSA TVRKFMVGYE MLAQAQRDLT PEQAAERLRA LPEVHYHLGQ KDRETATIA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards