About Uromodulin
Uromodulin (UMOD) is a protein
from Homo sapiens identified by UniProt accession
P07911, 640 residues long.
MolForge cross-references it against 0 known binders and
660 disease associations.
Target properties
| Protein name | Uromodulin |
|---|
| UniProt accession | P07911 |
|---|
| Gene | UMOD |
|---|
| Organism | Homo sapiens |
|---|
| Length | 640 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (660)
Diseases linked to this target (Open Targets).
- familial juvenile hyperuricemic nephropathy type 1 · score 0.82
- autosomal dominant medullary cystic kidney disease with or without hyperuricemia · score 0.67
- kidney disease · score 0.60
- Cystic Kidney Disease · score 0.46
- chronic kidney disease · score 0.45
- creatinine measurement · score 0.44
- glomerular filtration rate · score 0.42
- neurodegenerative disease · score 0.42
- genetic disorder · score 0.41
- cystatin C measurement · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07911-F1 | alphafold | PREDICTED | 82.95 | — |
Amino-acid sequence (640 residues)
MGQPSLTWML MVVVASWFIT TAATDTSEAR WCSECHSNAT CTEDEAVTTC TCQEGFTGDG LTCVDLDECA IPGAHNCSAN SSCVNTPGSF SCVCPEGFRL SPGLGCTDVD ECAEPGLSHC HALATCVNVV GSYLCVCPAG YRGDGWHCEC SPGSCGPGLD CVPEGDALVC ADPCQAHRTL DEYWRSTEYG EGYACDTDLR GWYRFVGQGG ARMAETCVPV LRCNTAAPMW LNGTHPSSDE GIVSRKACAH WSGHCCLWDA SVQVKACAGG YYVYNLTAPP ECHLAYCTDP SSVEGTCEEC SIDEDCKSNN GRWHCQCKQD FNITDISLLE HRLECGANDM KVSLGKCQLK SLGFDKVFMY LSDSRCSGFN DRDNRDWVSV VTPARDGPCG TVLTRNETHA TYSNTLYLAD EIIIRDLNIK INFACSYPLD MKVSLKTALQ PMVSALNIRV GGTGMFTVRM ALFQTPSYTQ PYQGSSVTLS TEAFLYVGTM LDGGDLSRFA LLMTNCYATP SSNATDPLKY FIIQDRCPHT RDSTIQVVEN GESSQGRFSV QMFRFAGNYD LVYLHCEVYL CDTMNEKCKP TCSGTRFRSG SVIDQSRVLN LGPITRKGVQ ATVSRAFSSL GLLKVWLPLL LSATLTLTFQ
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