About Tropomyosin beta chain
Tropomyosin beta chain (TPM2) is a protein
from Homo sapiens identified by UniProt accession
P07951, 284 residues long.
MolForge cross-references it against 0 known binders and
243 disease associations.
Target properties
| Protein name | Tropomyosin beta chain |
|---|
| UniProt accession | P07951 |
|---|
| Gene | TPM2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 284 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (243)
Diseases linked to this target (Open Targets).
- congenital myopathy 23 · score 0.81
- digitotalar dysmorphism · score 0.71
- cap myopathy · score 0.64
- nemaline myopathy · score 0.64
- Sheldon-hall syndrome · score 0.62
- arthrogryposis, distal, type 2B4 · score 0.55
- TPM2-related myopathy · score 0.44
- congenital fiber-type disproportion myopathy · score 0.41
- arthrogryposis multiplex congenita · score 0.40
- congenital myopathy · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07951-F1 | alphafold | PREDICTED | 91.45 | — |
Amino-acid sequence (284 residues)
MDAIKKKMQM LKLDKENAID RAEQAEADKK QAEDRCKQLE EEQQALQKKL KGTEDEVEKY SESVKEAQEK LEQAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA DESERGMKVI ENRAMKDEEK MELQEMQLKE AKHIAEDSDR KYEEVARKLV ILEGELERSE ERAEVAESKC GDLEEELKIV TNNLKSLEAQ ADKYSTKEDK YEEEIKLLEE KLKEAETRAE FAERSVAKLE KTIDDLEDEV YAQKMKYKAI SEELDNALND ITSL
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