About Fumarate hydratase, mitochondrial
Fumarate hydratase, mitochondrial (FH) is a protein
from Homo sapiens identified by UniProt accession
P07954, 510 residues long.
MolForge cross-references it against 0 known binders and
289 disease associations.
Target properties
| Protein name | Fumarate hydratase, mitochondrial |
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| UniProt accession | P07954 |
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| Gene | FH |
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| Organism | Homo sapiens |
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| Length | 510 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (289)
Diseases linked to this target (Open Targets).
- hereditary leiomyomatosis and renal cell cancer · score 0.85
- fumaric aciduria · score 0.82
- hereditary neoplastic syndrome · score 0.58
- Inherited cancer-predisposing syndrome · score 0.57
- Multiple cutaneous leiomyomas · score 0.57
- neurodegenerative disease · score 0.48
- kidney neoplasm · score 0.44
- renal carcinoma · score 0.42
- ovarian cancer · score 0.39
- neuroendocrine carcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07954-F1 | alphafold | PREDICTED | 92.70 | — |
Amino-acid sequence (510 residues)
MYRALRLLAR SRPLVRAPAA ALASAPGLGG AAVPSFWPPN AARMASQNSF RIEYDTFGEL KVPNDKYYGA QTVRSTMNFK IGGVTERMPT PVIKAFGILK RAAAEVNQDY GLDPKIANAI MKAADEVAEG KLNDHFPLVV WQTGSGTQTN MNVNEVISNR AIEMLGGELG SKIPVHPNDH VNKSQSSNDT FPTAMHIAAA IEVHEVLLPG LQKLHDALDA KSKEFAQIIK IGRTHTQDAV PLTLGQEFSG YVQQVKYAMT RIKAAMPRIY ELAAGGTAVG TGLNTRIGFA EKVAAKVAAL TGLPFVTAPN KFEALAAHDA LVELSGAMNT TACSLMKIAN DIRFLGSGPR SGLGELILPE NEPGSSIMPG KVNPTQCEAM TMVAAQVMGN HVAVTVGGSN GHFELNVFKP MMIKNVLHSA RLLGDASVSF TENCVVGIQA NTERINKLMN ESLMLVTALN PHIGYDKAAK IAKTAHKNGS TLKETAIELG YLTAEQFDEW VKPKDMLGPK
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