About Pulmonary surfactant-associated protein B
Pulmonary surfactant-associated protein B (SFTPB) is a protein
from Homo sapiens identified by UniProt accession
P07988, 381 residues long.
MolForge cross-references it against 0 known binders and
233 disease associations.
Target properties
| Protein name | Pulmonary surfactant-associated protein B |
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| UniProt accession | P07988 |
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| Gene | SFTPB |
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| Organism | Homo sapiens |
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| Length | 381 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (233)
Diseases linked to this target (Open Targets).
- surfactant metabolism dysfunction, pulmonary, 1 · score 0.74
- Neonatal acute respiratory distress with surfactant metabolism deficiency · score 0.68
- hereditary pulmonary alveolar proteinosis · score 0.52
- newborn respiratory distress syndrome · score 0.47
- Congenital pulmonary alveolar proteinosis · score 0.47
- interstitial lung disease · score 0.38
- respiratory distress syndrome in premature infants · score 0.38
- blood protein measurement · score 0.29
- cutaneous melanoma · score 0.24
- squamous cell lung carcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07988-F1 | alphafold | PREDICTED | 73.06 | — |
Amino-acid sequence (381 residues)
MAESHLLQWL LLLLPTLCGP GTAAWTTSSL ACAQGPEFWC QSLEQALQCR ALGHCLQEVW GHVGADDLCQ ECEDIVHILN KMAKEAIFQD TMRKFLEQEC NVLPLKLLMP QCNQVLDDYF PLVIDYFQNQ TDSNGICMHL GLCKSRQPEP EQEPGMSDPL PKPLRDPLPD PLLDKLVLPV LPGALQARPG PHTQDLSEQQ FPIPLPYCWL CRALIKRIQA MIPKGALAVA VAQVCRVVPL VAGGICQCLA ERYSVILLDT LLGRMLPQLV CRLVLRCSMD DSAGPRSPTG EWLPRDSECH LCMSVTTQAG NSSEQAIPQA MLQACVGSWL DREKCKQFVE QHTPQLLTLV PRGWDAHTTC QALGVCGTMS SPLQCIHSPD L
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