DNA excision repair protein ERCC-1 (ERCC1)

About DNA excision repair protein ERCC-1

DNA excision repair protein ERCC-1 (ERCC1) is a protein from Homo sapiens identified by UniProt accession P07992, 297 residues long. MolForge cross-references it against 0 known binders and 388 disease associations.

Target properties

Protein name	DNA excision repair protein ERCC-1
UniProt accession	P07992
Gene	ERCC1
Organism	Homo sapiens
Length	297 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (388)

Diseases linked to this target (Open Targets).

COFS syndrome · score 0.73
Fanconi anemia · score 0.51
Failure to thrive · score 0.42
Premature ovarian insufficiency · score 0.42
Cutaneous photosensitivity · score 0.42
xeroderma pigmentosum · score 0.38
Cockayne syndrome type 2 · score 0.37
thyroid hormone metabolism, abnormal 1 · score 0.33
thyroid hormone metabolism, abnormal, 3 · score 0.33
lung carcinoma · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P07992-F1	alphafold	PREDICTED	76.25	—

Amino-acid sequence (297 residues)

MDPGKDKEGV PQPSGPPARK KFVIPLDEDE VPPGVAKPLF RSTQSLPTVD TSAQAAPQTY AEYAISQPLE GAGATCPTGS EPLAGETPNQ ALKPGAKSNS IIVSPRQRGN PVLKFVRNVP WEFGDVIPDY VLGQSTCALF LSLRYHNLHP DYIHGRLQSL GKNFALRVLL VQVDVKDPQQ ALKELAKMCI LADCTLILAW SPEEAGRYLE TYKAYEQKPA DLLMEKLEQD FVSRVTECLT TVKSVNKTDS QTLLTTFGSL EQLIAASRED LALCPGLGPQ KARRLFDVLH EPFLKVP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards