Ribonuclease pancreatic (RNASE1)

About Ribonuclease pancreatic

Ribonuclease pancreatic (RNASE1) is a protein from Homo sapiens identified by UniProt accession P07998, 156 residues long. MolForge cross-references it against 0 known binders and 195 disease associations.

Target properties

Protein name	Ribonuclease pancreatic
UniProt accession	P07998
Gene	RNASE1
Organism	Homo sapiens
Length	156 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (195)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.21
visual perception measurement · score 0.14
neoplasm · score 0.11
hepatocellular carcinoma · score 0.08
permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome · score 0.07
cancer · score 0.06
COVID-19 · score 0.05
Barrett's esophagus · score 0.05
Sepsis · score 0.04
breast cancer · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P07998-F1	alphafold	PREDICTED	92.53	—

Amino-acid sequence (156 residues)

MALEKSLVRL LLLVLILLVL GWVQPSLGKE SRAKKFQRQH MDSDSSPSSS STYCNQMMRR RNMTQGRCKP VNTFVHEPLV DVQNVCFQEK VTCKNGQGNC YKSNSSMHIT DCRLTNGSRY PNCAYRTSPK ERHIIVACEG SPYVPVHFDA SVEDST

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards