About Tumor necrosis factor receptor superfamily member 16
Tumor necrosis factor receptor superfamily member 16 (NGFR) is a protein
from Homo sapiens identified by UniProt accession
P08138, 427 residues long.
MolForge cross-references it against 0 known binders and
693 disease associations.
Target properties
| Protein name | Tumor necrosis factor receptor superfamily member 16 |
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| UniProt accession | P08138 |
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| Gene | NGFR |
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| Organism | Homo sapiens |
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| Length | 427 residues |
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| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (693)
Diseases linked to this target (Open Targets).
- body height · score 0.31
- protein measurement · score 0.22
- neurofibrillary tangles measurement · score 0.21
- cutaneous melanoma · score 0.19
- lung adenocarcinoma · score 0.18
- squamous cell lung carcinoma · score 0.12
- neoplasm · score 0.12
- melanoma · score 0.12
- esophageal squamous cell carcinoma · score 0.10
- gastric adenocarcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08138-F1 | alphafold | PREDICTED | 75.87 | — |
Amino-acid sequence (427 residues)
MGAGATGRAM DGPRLLLLLL LGVSLGGAKE ACPTGLYTHS GECCKACNLG EGVAQPCGAN QTVCEPCLDS VTFSDVVSAT EPCKPCTECV GLQSMSAPCV EADDAVCRCA YGYYQDETTG RCEACRVCEA GSGLVFSCQD KQNTVCEECP DGTYSDEANH VDPCLPCTVC EDTERQLREC TRWADAECEE IPGRWITRST PPEGSDSTAP STQEPEAPPE QDLIASTVAG VVTTVMGSSQ PVVTRGTTDN LIPVYCSILA AVVVGLVAYI AFKRWNSCKQ NKQGANSRPV NQTPPPEGEK LHSDSGISVD SQSLHDQQPH TQTASGQALK GDGGLYSSLP PAKREEVEKL LNGSAGDTWR HLAGELGYQP EHIDSFTHEA CPVRALLASW ATQDSATLDA LLAALRRIQR ADLVESLCSE STATSPV
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