Complement decay-accelerating factor (CD55)

About Complement decay-accelerating factor

Complement decay-accelerating factor (CD55) is a protein from Homo sapiens identified by UniProt accession P08174, 381 residues long. MolForge cross-references it against 0 known binders and 466 disease associations.

Target properties

Protein name	Complement decay-accelerating factor
UniProt accession	P08174
Gene	CD55
Organism	Homo sapiens
Length	381 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (466)

Diseases linked to this target (Open Targets).

Protein-losing enteropathy · score 0.62
primary intestinal lymphangiectasia · score 0.46
refractive error · score 0.38
blood protein measurement · score 0.33
Myopia · score 0.33
refractive error measurement · score 0.31
self reported educational attainment · score 0.29
age at onset · score 0.26
complement decay-accelerating factor measurement · score 0.25
Hypermetropia · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08174-F1	alphafold	PREDICTED	78.27	—

Amino-acid sequence (381 residues)

MTVARPSVPA ALPLLGELPR LLLLVLLCLP AVWGDCGLPP DVPNAQPALE GRTSFPEDTV ITYKCEESFV KIPGEKDSVI CLKGSQWSDI EEFCNRSCEV PTRLNSASLK QPYITQNYFP VGTVVEYECR PGYRREPSLS PKLTCLQNLK WSTAVEFCKK KSCPNPGEIR NGQIDVPGGI LFGATISFSC NTGYKLFGST SSFCLISGSS VQWSDPLPEC REIYCPAPPQ IDNGIIQGER DHYGYRQSVT YACNKGFTMI GEHSIYCTVN NDEGEWSGPP PECRGKSLTS KVPPTVQKPT TVNVPTTEVS PTSQKTTTKT TTPNAQATRS TPVSRTTKHF HETTPNKGSG TTSGTTRLLS GHTCFTLTGL LGTLVTMGLL T

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards