About Amino acid transporter heavy chain SLC3A2
Amino acid transporter heavy chain SLC3A2 (SLC3A2) is a protein
from Homo sapiens identified by UniProt accession
P08195, 529 residues long.
MolForge cross-references it against 0 known binders and
269 disease associations.
Target properties
| Protein name | Amino acid transporter heavy chain SLC3A2 |
|---|
| UniProt accession | P08195 |
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| Gene | SLC3A2 |
|---|
| Organism | Homo sapiens |
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| Length | 529 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (269)
Diseases linked to this target (Open Targets).
- Sensorineural hearing impairment · score 0.37
- neurodegenerative disease · score 0.32
- glioblastoma multiforme · score 0.19
- breast adenocarcinoma · score 0.18
- head and neck squamous cell carcinoma · score 0.13
- neoplasm · score 0.11
- breast cancer · score 0.10
- cancer · score 0.10
- lung adenocarcinoma · score 0.09
- Miyoshi myopathy · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08195-F1 | alphafold | PREDICTED | 78.69 | — |
Amino-acid sequence (529 residues)
MSQDTEVDMK EVELNELEPE KQPMNAASGA AMSLAGAEKN GLVKIKVAED EAEAAAAAKF TGLSKEELLK VAGSPGWVRT RWALLLLFWL GWLGMLAGAV VIIVRAPRCR ELPAQKWWHT GALYRIGDLQ AFQGHGAGNL AGLKGRLDYL SSLKVKGLVL GPIHKNQKDD VAQTDLLQID PNFGSKEDFD SLLQSAKKKS IRVILDLTPN YRGENSWFST QVDTVATKVK DALEFWLQAG VDGFQVRDIE NLKDASSFLA EWQNITKGFS EDRLLIAGTN SSDLQQILSL LESNKDLLLT SSYLSDSGST GEHTKSLVTQ YLNATGNRWC SWSLSQARLL TSFLPAQLLR LYQLMLFTLP GTPVFSYGDE IGLDAAALPG QPMEAPVMLW DESSFPDIPG AVSANMTVKG QSEDPGSLLS LFRRLSDQRS KERSLLHGDF HAFSAGPGLF SYIRHWDQNE RFLVVLNFGD VGLSAGLQAS DLPASASLPA KADLLLSTQP GREEGSPLEL ERLKLEPHEG LLLRFPYAA
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