Chymotrypsin-like elastase family member 2A (CELA2A)

About Chymotrypsin-like elastase family member 2A

Chymotrypsin-like elastase family member 2A (CELA2A) is a protein from Homo sapiens identified by UniProt accession P08217, 269 residues long. MolForge cross-references it against 0 known binders and 117 disease associations.

Target properties

Protein name	Chymotrypsin-like elastase family member 2A
UniProt accession	P08217
Gene	CELA2A
Organism	Homo sapiens
Length	269 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (117)

Diseases linked to this target (Open Targets).

abdominal obesity-metabolic syndrome 4 · score 0.63
Hypertriglyceridemia · score 0.47
hypertensive disorder · score 0.47
coronary artery disease · score 0.47
hypertension · score 0.47
systolic blood pressure · score 0.27
breast adenocarcinoma · score 0.22
ovarian cancer · score 0.18
head and neck squamous cell carcinoma · score 0.18
pulse pressure measurement · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08217-F1	alphafold	PREDICTED	93.43	—

Amino-acid sequence (269 residues)

MIRTLLLSTL VAGALSCGDP TYPPYVTRVV GGEEARPNSW PWQVSLQYSS NGKWYHTCGG SLIANSWVLT AAHCISSSRT YRVGLGRHNL YVAESGSLAV SVSKIVVHKD WNSNQISKGN DIALLKLANP VSLTDKIQLA CLPPAGTILP NNYPCYVTGW GRLQTNGAVP DVLQQGRLLV VDYATCSSSA WWGSSVKTSM ICAGGDGVIS SCNGDSGGPL NCQASDGRWQ VHGIVSFGSR LGCNYYHKPS VFTRVSNYID WINSVIANN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards