Chymotrypsin-like elastase family member 2B (CELA2B)

About Chymotrypsin-like elastase family member 2B

Chymotrypsin-like elastase family member 2B (CELA2B) is a protein from Homo sapiens identified by UniProt accession P08218, 269 residues long. MolForge cross-references it against 0 known binders and 105 disease associations.

Target properties

Protein name	Chymotrypsin-like elastase family member 2B
UniProt accession	P08218
Gene	CELA2B
Organism	Homo sapiens
Length	269 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (105)

Diseases linked to this target (Open Targets).

systolic blood pressure · score 0.32
pulse pressure measurement · score 0.20
body mass index · score 0.18
hemoglobin measurement · score 0.07
glomerular filtration rate · score 0.07
hypertrophic cardiomyopathy · score 0.07
erythrocyte count · score 0.07
creatinine measurement · score 0.07
Romano-Ward syndrome · score 0.06
hematocrit · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08218-F1	alphafold	PREDICTED	92.14	—

Amino-acid sequence (269 residues)

MIRTLLLSTL VAGALSCGVS TYAPDMSRML GGEEARPNSW PWQVSLQYSS NGQWYHTCGG SLIANSWVLT AAHCISSSGI YRVMLGQHNL YVAESGSLAV SVSKIVVHKD WNSDQVSKGN DIALLKLANP VSLTDKIQLA CLPPAGTILP NNYPCYVTGW GRLQTNGALP DDLKQGQLLV VDYATCSSSG WWGSTVKTNM ICAGGDGVIC TCNGDSGGPL NCQASDGRWE VHGIGSLTSV LGCNYYYKPS IFTRVSNYND WINSVIANN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards