About Beta-glucuronidase
Beta-glucuronidase (GUSB) is a protein
from Homo sapiens identified by UniProt accession
P08236, 651 residues long.
MolForge cross-references it against 0 known binders and
392 disease associations.
Target properties
| Protein name | Beta-glucuronidase |
|---|
| UniProt accession | P08236 |
|---|
| Gene | GUSB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 651 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (392)
Diseases linked to this target (Open Targets).
- mucopolysaccharidosis type 7 · score 0.88
- mucopolysaccharidosis type 6 · score 0.43
- mucopolysaccharidosis · score 0.43
- genetic disorder · score 0.41
- Non-immune hydrops fetalis · score 0.39
- Hydrops fetalis · score 0.37
- hydrops fetalis · score 0.37
- monocyte count · score 0.26
- neutrophil count · score 0.20
- alkaline phosphatase measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08236-F1 | alphafold | PREDICTED | 93.89 | — |
Amino-acid sequence (651 residues)
MARGSAVAWA ALGPLLWGCA LGLQGGMLYP QESPSRECKE LDGLWSFRAD FSDNRRRGFE EQWYRRPLWE SGPTVDMPVP SSFNDISQDW RLRHFVGWVW YEREVILPER WTQDLRTRVV LRIGSAHSYA IVWVNGVDTL EHEGGYLPFE ADISNLVQVG PLPSRLRITI AINNTLTPTT LPPGTIQYLT DTSKYPKGYF VQNTYFDFFN YAGLQRSVLL YTTPTTYIDD ITVTTSVEQD SGLVNYQISV KGSNLFKLEV RLLDAENKVV ANGTGTQGQL KVPGVSLWWP YLMHERPAYL YSLEVQLTAQ TSLGPVSDFY TLPVGIRTVA VTKSQFLING KPFYFHGVNK HEDADIRGKG FDWPLLVKDF NLLRWLGANA FRTSHYPYAE EVMQMCDRYG IVVIDECPGV GLALPQFFNN VSLHHHMQVM EEVVRRDKNH PAVVMWSVAN EPASHLESAG YYLKMVIAHT KSLDPSRPVT FVSNSNYAAD KGAPYVDVIC LNSYYSWYHD YGHLELIQLQ LATQFENWYK KYQKPIIQSE YGAETIAGFH QDPPLMFTEE YQKSLLEQYH LGLDQKRRKY VVGELIWNFA DFMTEQSPTR VLGNKKGIFT RQRQPKSAAF LLRERYWKIA NETRYPHSVA KSQCLENSLF T
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