About Asparagine synthetase [glutamine-hydrolyzing]
Asparagine synthetase [glutamine-hydrolyzing] (ASNS) is a protein
from Homo sapiens identified by UniProt accession
P08243, 561 residues long.
MolForge cross-references it against 0 known binders and
165 disease associations.
Target properties
| Protein name | Asparagine synthetase [glutamine-hydrolyzing] |
|---|
| UniProt accession | P08243 |
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| Gene | ASNS |
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| Organism | Homo sapiens |
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| Length | 561 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (165)
Diseases linked to this target (Open Targets).
- congenital microcephaly - severe encephalopathy - progressive cerebral atrophy syndrome · score 0.80
- Congenital microcephaly-severe encephalopathy-progressive cerebral atrophy syndrome · score 0.80
- genetic disorder · score 0.47
- Neurodevelopmental delay · score 0.43
- Neurodevelopmental abnormality · score 0.29
- neoplasm · score 0.09
- hepatocellular carcinoma · score 0.09
- acute lymphoblastic leukemia · score 0.09
- acute myeloid leukemia · score 0.08
- retinitis pigmentosa · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08243-F1 | alphafold | PREDICTED | 94.24 | — |
Amino-acid sequence (561 residues)
MCGIWALFGS DDCLSVQCLS AMKIAHRGPD AFRFENVNGY TNCCFGFHRL AVVDPLFGMQ PIRVKKYPYL WLCYNGEIYN HKKMQQHFEF EYQTKVDGEI ILHLYDKGGI EQTICMLDGV FAFVLLDTAN KKVFLGRDTY GVRPLFKAMT EDGFLAVCSE AKGLVTLKHS ATPFLKVEPF LPGHYEVLDL KPNGKVASVE MVKYHHCRDV PLHALYDNVE KLFPGFEIET VKNNLRILFN NAVKKRLMTD RRIGCLLSGG LDSSLVAATL LKQLKEAQVQ YPLQTFAIGM EDSPDLLAAR KVADHIGSEH YEVLFNSEEG IQALDEVIFS LETYDITTVR ASVGMYLISK YIRKNTDSVV IFSGEGSDEL TQGYIYFHKA PSPEKAEEES ERLLRELYLF DVLRADRTTA AHGLELRVPF LDHRFSSYYL SLPPEMRIPK NGIEKHLLRE TFEDSNLIPK EILWRPKEAF SDGITSVKNS WFKILQEYVE HQVDDAMMAN AAQKFPFNTP KTKEGYYYRQ VFERHYPGRA DWLSHYWMPK WINATDPSAR TLTHYKSAVK A
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