Glutathione S-transferase A1 (GSTA1)

About Glutathione S-transferase A1

Glutathione S-transferase A1 (GSTA1) is a protein from Homo sapiens identified by UniProt accession P08263, 222 residues long. MolForge cross-references it against 0 known binders and 201 disease associations.

Target properties

Protein name	Glutathione S-transferase A1
UniProt accession	P08263
Gene	GSTA1
Organism	Homo sapiens
Length	222 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (201)

Diseases linked to this target (Open Targets).

platelet count · score 0.44
hemoglobin measurement · score 0.43
Red cell distribution width · score 0.41
hematocrit · score 0.39
mean corpuscular volume · score 0.39
mean corpuscular hemoglobin concentration · score 0.37
testosterone measurement · score 0.36
platelet crit · score 0.35
triglyceride measurement · score 0.33
creatinine measurement · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08263-F1	alphafold	PREDICTED	97.51	—

Amino-acid sequence (222 residues)

MAEKPKLHYF NARGRMESTR WLLAAAGVEF EEKFIKSAED LDKLRNDGYL MFQQVPMVEI DGMKLVQTRA ILNYIASKYN LYGKDIKERA LIDMYIEGIA DLGEMILLLP VCPPEEKDAK LALIKEKIKN RYFPAFEKVL KSHGQDYLVG NKLSRADIHL VELLYYVEEL DSSLISSFPL LKALKTRISN LPTVKKFLQP GSPRKPPMDE KSLEEARKIF RF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards