About Cathepsin G
Cathepsin G (CTSG) is a protein
from Homo sapiens identified by UniProt accession
P08311, 255 residues long.
MolForge cross-references it against 0 known binders and
539 disease associations.
Target properties
| Protein name | Cathepsin G |
|---|
| UniProt accession | P08311 |
|---|
| Gene | CTSG |
|---|
| Organism | Homo sapiens |
|---|
| Length | 255 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (539)
Diseases linked to this target (Open Targets).
- tuberculosis · score 0.37
- lung adenocarcinoma · score 0.25
- cutaneous melanoma · score 0.24
- breast adenocarcinoma · score 0.24
- head and neck squamous cell carcinoma · score 0.23
- endometrial cancer · score 0.22
- glioblastoma multiforme · score 0.20
- ovarian cancer · score 0.18
- squamous cell lung carcinoma · score 0.17
- acute myeloid leukemia · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08311-F1 | alphafold | PREDICTED | 91.37 | — |
Amino-acid sequence (255 residues)
MQPLLLLLAF LLPTGAEAGE IIGGRESRPH SRPYMAYLQI QSPAGQSRCG GFLVREDFVL TAAHCWGSNI NVTLGAHNIQ RRENTQQHIT ARRAIRHPQY NQRTIQNDIM LLQLSRRVRR NRNVNPVALP RAQEGLRPGT LCTVAGWGRV SMRRGTDTLR EVQLRVQRDR QCLRIFGSYD PRRQICVGDR RERKAAFKGD SGGPLLCNNV AHGIVSYGKS SGVPPEVFTR VSSFLPWIRT TMRSFKLLDQ METPL
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