All-trans-retinol dehydrogenase [NAD(+)] ADH4 (ADH4)

About All-trans-retinol dehydrogenase [NAD(+)] ADH4

All-trans-retinol dehydrogenase [NAD(+)] ADH4 (ADH4) is a protein from Homo sapiens identified by UniProt accession P08319, 380 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.

Target properties

Protein name	All-trans-retinol dehydrogenase [NAD(+)] ADH4
UniProt accession	P08319
Gene	ADH4
Organism	Homo sapiens
Length	380 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (86)

Diseases linked to this target (Open Targets).

alkaline phosphatase measurement · score 0.45
platelet count · score 0.42
mean platelet volume · score 0.42
sex hormone-binding globulin measurement · score 0.41
bilirubin measurement · score 0.38
blood protein measurement · score 0.35
apolipoprotein A 1 measurement · score 0.33
triglyceride measurement · score 0.33
factor VII measurement · score 0.33
insulin like growth factor measurement · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08319-F1	alphafold	PREDICTED	98.19	—

Amino-acid sequence (380 residues)

MGTKGKVIKC KAAIAWEAGK PLCIEEVEVA PPKAHEVRIQ IIATSLCHTD ATVIDSKFEG LAFPVIVGHE AAGIVESIGP GVTNVKPGDK VIPLYAPLCR KCKFCLSPLT NLCGKISNLK SPASDQQLME DKTSRFTCKG KPVYHFFGTS TFSQYTVVSD INLAKIDDDA NLERVCLLGC GFSTGYGAAI NNAKVTPGST CAVFGLGGVG LSAVMGCKAA GASRIIGIDI NSEKFVKAKA LGATDCLNPR DLHKPIQEVI IELTKGGVDF ALDCAGGSET MKAALDCTTA GWGSCTFIGV AAGSKGLTIF PEELIIGRTI NGTFFGGWKS VDSIPKLVTD YKNKKFNLDA LVTHTLPFDK ISEAFDLMNQ GKSVRTILIF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards