Porphobilinogen deaminase (HMBS)

About Porphobilinogen deaminase

Porphobilinogen deaminase (HMBS) is a protein from Homo sapiens identified by UniProt accession P08397, 361 residues long. MolForge cross-references it against 0 known binders and 236 disease associations.

Target properties

Protein name	Porphobilinogen deaminase
UniProt accession	P08397
Gene	HMBS
Organism	Homo sapiens
Length	361 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (236)

Diseases linked to this target (Open Targets).

acute intermittent porphyria · score 0.86
encephalopathy, porphyria-related · score 0.70
leukoencephalopathy, porphyria-related · score 0.68
neurodegenerative disease · score 0.53
Leukoencephalopathy · score 0.45
Abdominal pain · score 0.40
hereditary peripheral neuropathy · score 0.37
Visual loss · score 0.34
Emotional lability · score 0.34
Vomiting · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08397-F1	alphafold	PREDICTED	90.07	—

Amino-acid sequence (361 residues)

MSGNGNAAAT AEENSPKMRV IRVGTRKSQL ARIQTDSVVA TLKASYPGLQ FEIIAMSTTG DKILDTALSK IGEKSLFTKE LEHALEKNEV DLVVHSLKDL PTVLPPGFTI GAICKRENPH DAVVFHPKFV GKTLETLPEK SVVGTSSLRR AAQLQRKFPH LEFRSIRGNL NTRLRKLDEQ QEFSAIILAT AGLQRMGWHN RVGQILHPEE CMYAVGQGAL GVEVRAKDQD ILDLVGVLHD PETLLRCIAE RAFLRHLEGG CSVPVAVHTA MKDGQLYLTG GVWSLDGSDS IQETMQATIH VPAQHEDGPE DDPQLVGITA RNIPRGPQLA AQNLGISLAN LLLSKGAKNI LDVARQLNDA H

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards