Inhibin beta A chain (INHBA)

About Inhibin beta A chain

Inhibin beta A chain (INHBA) is a protein from Homo sapiens identified by UniProt accession P08476, 426 residues long. MolForge cross-references it against 0 known binders and 344 disease associations.

Target properties

Protein name	Inhibin beta A chain
UniProt accession	P08476
Gene	INHBA
Organism	Homo sapiens
Length	426 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (344)

Diseases linked to this target (Open Targets).

pulmonary arterial hypertension · score 0.51
ovarian adenocarcinoma · score 0.37
pulse pressure measurement · score 0.31
fibrodysplasia ossificans progressiva · score 0.28
creatinine measurement · score 0.27
self reported educational attainment · score 0.27
sex hormone-binding globulin measurement · score 0.27
age at menarche · score 0.25
low density lipoprotein cholesterol measurement · score 0.25
urate measurement · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08476-F1	alphafold	PREDICTED	76.01	—

Amino-acid sequence (426 residues)

MPLLWLRGFL LASCWIIVRS SPTPGSEGHS AAPDCPSCAL AALPKDVPNS QPEMVEAVKK HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY VEIEDDIGRR AEMNELMEQT SEIITFAESG TARKTLHFEI SKEGSDLSVV ERAEVWLFLK VPKANRTRTK VTIRLFQQQK HPQGSLDTGE EAEEVGLKGE RSELLLSEKV VDARKSTWHV FPVSSSIQRL LDQGKSSLDV RIACEQCQES GASLVLLGKK KKKEEEGEGK KKGGGEGGAG ADEEKEQSHR PFLMLQARQS EDHPHRRRRR GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards