Matrix Gla protein (MGP)

About Matrix Gla protein

Matrix Gla protein (MGP) is a protein from Homo sapiens identified by UniProt accession P08493, 103 residues long. MolForge cross-references it against 0 known binders and 344 disease associations.

Target properties

Protein name	Matrix Gla protein
UniProt accession	P08493
Gene	MGP
Organism	Homo sapiens
Length	103 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (344)

Diseases linked to this target (Open Targets).

Keutel syndrome · score 0.74
spondyloepiphyseal dysplasia · score 0.40
Spondyloepiphyseal dysplasia · score 0.37
grip strength measurement · score 0.21
osteoarthritis, hand · score 0.20
blood protein measurement · score 0.20
creatinine measurement · score 0.18
heel bone mineral density · score 0.17
Short stature · score 0.12
Platyspondyly · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08493-F1	alphafold	PREDICTED	82.82	—

Amino-acid sequence (103 residues)

MKSLILLAIL AALAVVTLCY ESHESMESYE LNPFINRRNA NTFISPQQRW RAKVQERIRE RSKPVHELNR EACDDYRLCE RYAMVYGYNA AYNRYFRKRR GTK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards