About Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1) is a protein
from Homo sapiens identified by UniProt accession
P08559, 390 residues long.
MolForge cross-references it against 0 known binders and
198 disease associations.
Target properties
| Protein name | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial |
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| UniProt accession | P08559 |
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| Gene | PDHA1 |
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| Organism | Homo sapiens |
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| Length | 390 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (198)
Diseases linked to this target (Open Targets).
- pyruvate dehydrogenase E1-alpha deficiency · score 0.86
- pyruvate dehydrogenase deficiency · score 0.56
- genetic disorder · score 0.53
- Leigh syndrome · score 0.37
- Neurodevelopmental delay · score 0.34
- Abnormality of the mitochondrion · score 0.34
- sudden infant death syndrome · score 0.34
- neurodegenerative disease · score 0.27
- age at onset · score 0.25
- Myopia · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08559-F1 | alphafold | PREDICTED | 94.50 | — |
Amino-acid sequence (390 residues)
MRKMLAAVSR VLSGASQKPA SRVLVASRNF ANDATFEIKK CDLHRLEEGP PVTTVLTRED GLKYYRMMQT VRRMELKADQ LYKQKIIRGF CHLCDGQEAC CVGLEAGINP TDHLITAYRA HGFTFTRGLS VREILAELTG RKGGCAKGKG GSMHMYAKNF YGGNGIVGAQ VPLGAGIALA CKYNGKDEVC LTLYGDGAAN QGQIFEAYNM AALWKLPCIF ICENNRYGMG TSVERAAAST DYYKRGDFIP GLRVDGMDIL CVREATRFAA AYCRSGKGPI LMELQTYRYH GHSMSDPGVS YRTREEIQEV RSKSDPIMLL KDRMVNSNLA SVEELKEIDV EVRKEIEDAA QFATADPEPP LEELGYHIYS SDPPFEVRGA NQWIKFKSVS
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