About Pleckstrin
Pleckstrin (PLEK) is a protein
from Homo sapiens identified by UniProt accession
P08567, 350 residues long.
MolForge cross-references it against 0 known binders and
192 disease associations.
Target properties
| Protein name | Pleckstrin |
|---|
| UniProt accession | P08567 |
|---|
| Gene | PLEK |
|---|
| Organism | Homo sapiens |
|---|
| Length | 350 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (192)
Diseases linked to this target (Open Targets).
- platelet crit · score 0.57
- platelet component distribution width · score 0.55
- mean platelet volume · score 0.53
- lymphocyte count · score 0.51
- monocyte count · score 0.49
- mean corpuscular volume · score 0.46
- neutrophil percentage of leukocytes · score 0.42
- basophil count · score 0.41
- leukocyte count · score 0.40
- venous thromboembolism · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08567-F1 | alphafold | PREDICTED | 82.00 | — |
Amino-acid sequence (350 residues)
MEPKRIREGY LVKKGSVFNT WKPMWVVLLE DGIEFYKKKS DNSPKGMIPL KGSTLTSPCQ DFGKRMFVFK ITTTKQQDHF FQAAFLEERD AWVRDIKKAI KCIEGGQKFA RKSTRRSIRL PETIDLGALY LSMKDTEKGI KELNLEKDKK IFNHCFTGNC VIDWLVSNQS VRNRQEGLMI ASSLLNEGYL QPAGDMSKSA VDGTAENPFL DNPDAFYYFP DSGFFCEENS SDDDVILKEE FRGVIIKQGC LLKQGHRRKN WKVRKFILRE DPAYLHYYDP AGAEDPLGAI HLRGCVVTSV ESNSNGRKSE EENLFEIITA DEVHYFLQAA TPKERTEWIR AIQMASRTGK
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