About Monocyte differentiation antigen CD14
Monocyte differentiation antigen CD14 (CD14) is a protein
from Homo sapiens identified by UniProt accession
P08571, 375 residues long.
MolForge cross-references it against 0 known binders and
110 disease associations.
Target properties
| Protein name | Monocyte differentiation antigen CD14 |
|---|
| UniProt accession | P08571 |
|---|
| Gene | CD14 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 375 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (110)
Diseases linked to this target (Open Targets).
- inborn error of immunity · score 0.37
- blood protein measurement · score 0.35
- lung adenocarcinoma · score 0.28
- cutaneous melanoma · score 0.25
- head and neck squamous cell carcinoma · score 0.24
- breast adenocarcinoma · score 0.24
- squamous cell lung carcinoma · score 0.19
- gastric adenocarcinoma · score 0.17
- white matter microstructure measurement · score 0.15
- soluble CD14 measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08571-F1 | alphafold | PREDICTED | 84.73 | — |
Amino-acid sequence (375 residues)
MERASCLLLL LLPLVHVSAT TPEPCELDDE DFRCVCNFSE PQPDWSEAFQ CVSAVEVEIH AGGLNLEPFL KRVDADADPR QYADTVKALR VRRLTVGAAQ VPAQLLVGAL RVLAYSRLKE LTLEDLKITG TMPPLPLEAT GLALSSLRLR NVSWATGRSW LAELQQWLKP GLKVLSIAQA HSPAFSCEQV RAFPALTSLD LSDNPGLGER GLMAALCPHK FPAIQNLALR NTGMETPTGV CAALAAAGVQ PHSLDLSHNS LRATVNPSAP RCMWSSALNS LNLSFAGLEQ VPKGLPAKLR VLDLSCNRLN RAPQPDELPE VDNLTLDGNP FLVPGTALPH EGSMNSGVVP ACARSTLSVG VSGTLVLLQG ARGFA
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